17 January 2011 Last updated at 10:25 ET 
Mr Jobs is credited with turning around the fortunes of the company
He said he would continue as chief executive of Apple and be involved in any major decisions. Day-to-day running of the company will pass to Tim Cook.
In late 2008 to mid-2009 Mr Jobs was absent from Apple for six months to have a liver transplant.
It was part of the series of treatments he has undergone for pancreatic cancer. He was first diagnosed as suffering from the cancer in 2004 and underwent surgery later that year to remove a tumour from his pancreas.
"I have asked Tim Cook to be responsible for all of Apple's day to day operations."
Mr Cook is currently the firm's chief operating officer. He has run the company day-to-day before now during previous times when Mr Jobs has been dealing with his health problems.
The announcement was made on a public holiday in the US when there is no trading in company stocks and shares.
However, Apple shares closed down 6.4% on the Frankfurt stock exchange. Year-on-year, they are up 79% and over 24 months up 328%.
The news comes ahead of Apple's first quarter results, due on 18 January.
Mr Jobs is an iconic presence at Apple and is widely credited as the architect of its current run of success based around products such as the iPad and iPhone.
The absence comes as Apple is rumoured to be preparing to launch the second version of its iPad - the successor to the tablet computer it launched in 2010.
©BBC 2011. All rights reserved. this article was not read, authorized and/or approved by Steve Jobs himself.
Apple boss Steve Jobs takes 'medical leave'
Mr Jobs is credited with turning around the fortunes of the company Apple boss Steve Jobs has announced that he is to take "medical leave" from the company.
In an e-mail to employees he said he was taking the break to focus on his health. He said he would continue as chief executive of Apple and be involved in any major decisions. Day-to-day running of the company will pass to Tim Cook.
In late 2008 to mid-2009 Mr Jobs was absent from Apple for six months to have a liver transplant.
It was part of the series of treatments he has undergone for pancreatic cancer. He was first diagnosed as suffering from the cancer in 2004 and underwent surgery later that year to remove a tumour from his pancreas.
Continue reading the main story 
There is no other technology firm - probably no other major business - whose shape and direction is so much in the hands of one man as Apple.
Steve Jobs is not only the public face of the company, at the launches of new devices like the iPad, he is involved in every minute detail of Apple products.
So for the last half dozen years every hint, every rumour about his health has sent shockwaves through the investment community and caused Apple's share price to plummet.
Each time he has returned to work after treatment, the company has tried to reassure its investors that its chief executive is now in good shape.
Then the gaunt appearance of the man in the trademark black sweater and jeans has started the rumour-mill turning again.
Apple's many fans will feel deep sympathy for Mr Jobs when he pleads for privacy for himself and his family - but its investors will be demanding more detail when Apple unveils its latest results on Tuesday
Analysis
Steve Jobs is not only the public face of the company, at the launches of new devices like the iPad, he is involved in every minute detail of Apple products.
So for the last half dozen years every hint, every rumour about his health has sent shockwaves through the investment community and caused Apple's share price to plummet.
Each time he has returned to work after treatment, the company has tried to reassure its investors that its chief executive is now in good shape.
Then the gaunt appearance of the man in the trademark black sweater and jeans has started the rumour-mill turning again.
Apple's many fans will feel deep sympathy for Mr Jobs when he pleads for privacy for himself and his family - but its investors will be demanding more detail when Apple unveils its latest results on Tuesday
In his e-mail Mr Jobs said he would be back at work as soon as he can.
"At my request, the board of directors has granted me a medical leave of absence so I can focus on my health. I will continue as CEO and be involved in major strategic decisions for the company," he said in an e-mail."I have asked Tim Cook to be responsible for all of Apple's day to day operations."
Mr Cook is currently the firm's chief operating officer. He has run the company day-to-day before now during previous times when Mr Jobs has been dealing with his health problems.
The announcement was made on a public holiday in the US when there is no trading in company stocks and shares.
However, Apple shares closed down 6.4% on the Frankfurt stock exchange. Year-on-year, they are up 79% and over 24 months up 328%.
The news comes ahead of Apple's first quarter results, due on 18 January.
Mr Jobs is an iconic presence at Apple and is widely credited as the architect of its current run of success based around products such as the iPad and iPhone.
The absence comes as Apple is rumoured to be preparing to launch the second version of its iPad - the successor to the tablet computer it launched in 2010.
©BBC 2011. All rights reserved. this article was not read, authorized and/or approved by Steve Jobs himself.
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